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It has been postulated that cytokines may have a direct effect on the hypothalamic–pituitary–gonadal axis.

In light of these studies, inflammation is likely to play a very important role in the pathogenesis of hypogonadism in cancer patients, and low testosterone can, in turn, exacerbate or maintain the pro-inflammatory state forming a vicious circle.Patients with cancer may have a component of both types of hypogonadism: primary (testicular, hypergonadotrophic, or with elevated luteinizing hormone—LH—and follicular stimulating hormone—FSH) and secondary (central, hypogonadotrophic, or with low or inappropriately normal FSH and LH).Factors associated with primary hypogonadism in this patient population include inflammatory cytokines and chemotherapeutic agents.Inflammation is thought to play an important role in the pathogenesis of hypogonadism in cancer patients.Cancer like other chronic diseases is a pro-inflammatory state with elevated levels of inflammatory cytokines [].




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Showing humor through text is a skill, and if the recipient really gets a giggle out of your note, it will be remembered all day.


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After his family immigrated to Brooklyn in 1994, he rededicated himself once again to professionally dancing, competing in the International Latin category, where he ranked second in the U. and seventh in the world among professional international Latin couples with his partner, Elena Grinenko, who would later join him as a pro on “Dancing with the Stars.” At age 16, Chmerkovskiy and his father opened a youth-oriented competitive dance studio, Rising Stars Dance Academy, in New Jersey on the second floor of a building his father owned in Ridgewood, New Jersey.


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Providing companionship and tender hand holds for beautiful older women is nothing new for Schnabel, who reportedly dated model Elle Macpherson a few years ago when she was 44 and he was 21.


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Among other family structures, 32.3 percent of adolescents living in stepfamilies, 36.7 percent of those living with two cohabiting biological parents, 39.5 percent of those whose parents are divorced, and 39.6 percent of those whose parents have never married have ever been in a fight.


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For someone who has a problem committing, Tinder might not be the most effective dating tool, and maybe Tinder’s impact depends on the specific person using it.


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As a matter of belief, doctrine, and religious practice, TCC reserves the term marriage for the covenant relationship between one man (husband) and one woman (wife) to the exclusion of all others, as ordained by God.


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