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Whether or not they were socially tolerated or accepted by any particular culture, the existence of intersex people was known to many ancient and pre-modern cultures.The Greek historian Diodorus Siculus wrote of "hermaphroditus" in the first century BCE that Hermaphroditus "is born with a physical body which is a combination of that of a man and that of a woman", and with supernatural properties.Mothers in east Africa may be accused of witchcraft, and the birth of an intersex child may be described as a curse.Infants, children and adolescents also experience "normalising" interventions on intersex persons that are medically unnecessary and the unnecessary pathologisation of variations in sex characteristics.Such interventions have been criticized by the World Health Organization, other UN bodies such as the Office of the High Commissioner for Human Rights, and an increasing number of regional and national institutions due to their adverse consequences, including trauma, impact on sexual function and sensation, and violation of rights to physical and mental integrity. Because people born with intersex bodies are seen as different, intersex infants, children, adolescents and adults "are often stigmatized and subjected to multiple human rights violations", including discrimination in education, healthcare, employment, sport, and public services.

Some later shifts in terminology have reflected advances in genetics, while other shifts are suggested to be due to pejorative associations.

Areas of concern include: non-consensual medical interventions; stigma, discrimination and equal treatment; access to reparations and justice; access to information and support, and legal recognition.

Stigmatization and discrimination from birth may include infanticide, abandonment and the stigmatization of families.

These developments have been accompanied by International Intersex Forums and increased cooperation amongst civil society organizations.

However, the implementation, codification and enforcement of intersex human rights in national legal systems remains slow.

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